Nature Methods-style interactive atlas

FORMA Atlas: The First 4D MRI Atlas of Brain Organoid Development

A scalable, noninvasive resource spanning >2,000 longitudinal volumes across cerebral, MGE, and midbrain lineages.

Atlas statistics (Sunburst) · Line ID
新窗口打开

Platform Features

A fully integrated platform for large-scale longitudinal monitoring of brain organoids

High-Throughput Imaging

15-well MRI-compatible plate enabling simultaneous imaging of multiple organoids

Large-scale Dataset

>2,000 longitudinal MRI volumes from three organoid lineages

Multi-Region Coverage

Cerebral, MGE, and Midbrain organoids for morphological diversity

Longitudinal Tracking

True longitudinal tracking over months with region-specific trajectories

Interactive Showcase

不止是静态图:用交互方式展示 MRI 与 AI 的价值,以及 DeepFORMA 的三大指标体系。

Before & After
raw / pred / gt(H5 交互切片)
Slice 9 / 1
200%
3D Reconstruction (PRED)
points: 0
The “Three Domains” of Deep Phenotyping
Morphology
3D surface & shape descriptors
Step4e Cross-section (z=5, ±1) (PRED)
Volume
voxels
Sphericity
shape
SA/V
ratio
Spatial Pattern
radial intensity signature (RIS)
Step4c Heatmap 3D (PRED)
RIS gradientLayeringEdge contrast
Tissue State
T2 signal & composition
CountT2 Intensity
用 T2 信号分布刻画组织状态(例如“致密/水肿”等)。当前为展示占位,后续可直接接入你们的 histogram/伪彩图输出。

Technical Specifications

MRI Sequence

T2-weighted 3D RARE

Spatial Resolution

150 μm isotropic (atlas)

Field Strength

9.4T high-field MRI

Hardware Design

Custom 15-well plate with U-bottom geometry

Dataset Composition

Total Volumes

>2,000

longitudinal MRI volumes

Brain Regions

Cerebral, MGE, Midbrain

Genotypes

2 Healthy Control + 2 SCZ Patient-derived lines

Longitudinal Coverage

Months of developmental tracking